rhelief® is a single-dose 2.0 oz. bottle of liquid pain relief that relies on scientifically validated ingredients to decrease pain and relieve pain caused by inflammation.
Feverfew (Tanectum Parthenium) is a powerful anti-inflammatory that inhibits the enzyme COX-2 to produce its pain relieving properties. It also has a pain relieving component. The bioactive extract is 0.8% parthenolide. It inhibits the expression of the inflammatory enzyme COX-2. It also inhibits production of pro-inflammatory cytokines THF-alpha and IL-1. vitamin d3 Vitamin D3 provides supplementation for a deficiency found in 70 percent of people with pain. It is active in decreasing musculosketal inflammation and modulating nervous system pain activity. Low D3 leads to poor bone mineralization which causes chronic dull musculosketal aches and pains. Vitamin D3 decreases pro-inflammatory cytokines and increases anti-inflammatory ones. D3 supplementation also assists in the relief of neuropathic pain.
Butterbur (Pestasites Hybridus) has a pain relieving component. The bioactive extract is 15% pestasines. It inhibits smooth muscle contraction which relieves pain. It also inhibits leukotriene synthesis creating an anti-inflammatory action to relieve joint and muscle pain. Provides pain relief by inhibiting smooth muscle contraction and the anti-inflammatory cascade.
Phenylalanine is a fast-acting amino acid that increases the body’s own pain defenses such as endorphins. Endorphins and enkephalins are natural pain killers that are 1000 times as potent as morphine. Phenylalanine blocks the enzyme in the body that breaks down endorphins and enkephalins. Patients have received pain relief in a little as 10 minutes after ingestion of 500mg of phenylalanine.
Arginine is a pain-relieving amino acid that acts on the receptors that cause and promote nerve pain. Arginine is metabolized to Agmatine and Ornithine. These are amino acids and often deficient in regular diets. Agmatine interacts with several molecular targets on nerve cells to provide neuro-protection and less nerve pain. Agmatine attenuates the pain-producing activity of glutamate, nicotine, NMDA and epinephrine. Agmatine regulates pain producing nitric oxide activity and serves as a building block for neuroprotective polyamines.
Caffeine is a central nervous system stimulant and is used to reduce physical fatigue and to prevent or treat drowsiness.  It produces increased wakefulness, increased focus, and better general body coordination.
Both caffeine and coffee are proven ergogenic aids in humans. Caffeine improves athletic performance in aerobic (especially endurance sports) and anaerobic conditions. Moderate doses of caffeine can improve sprint performance, cycling and running time trial performance, endurance (i.e., it delays the onset of muscle fatigue and central fatigue), and cycling power output.
Caffeine blocks receptors in the brain called, 'adenosines', which in turn induce relaxation and activate dopamine chemicals associated with both pain relief and energy. A study from the year 2009, summarized in Science Daily and conducted by the University of Illinois at Urbana Champaign indicates that small doses of caffeine prior to working out may prolong the duration of a person's exercise. It may also prohibit the pain a person might experience in their joints due to strenuous activity.