rhelief® is a single-dose 0.24 oz stick of quick acting powder pain relief that relies on scientifically validated ingredients to decrease pain and relieve pain caused by inflammation.
Feverfew (Tanectum Parthenium) is a powerful anti-inflammatory that inhibits the enzyme COX-2 to produce its pain relieving properties. It also has a pain relieving component. The bioactive extract is 0.8% parthenolide. It inhibits the expression of the inflammatory enzyme COX-2. It also inhibits production of pro-inflammatory cytokines THF-alpha and IL-1. v
Butterbur (Pestasites Hybridus) has a pain relieving component. The bioactive extract is 15% pestasines. It inhibits smooth muscle contraction which relieves pain. It also inhibits leukotriene synthesis creating an anti-inflammatory action to relieve joint and muscle pain. Provides pain relief by inhibiting smooth muscle contraction and the anti-inflammatory cascade.
Phenylalanine is a fast-acting amino acid that increases the body’s own pain defenses such as endorphins. Endorphins and enkephalins are natural pain killers. Phenylalanine blocks the enzyme in the body that breaks down endorphins and enkephalins. Patients have received pain relief in a little as 10 minutes after ingestion of 500mg of phenylalanine.
Arginine is a pain-relieving amino acid that acts on the receptors that cause and promote nerve pain. Arginine is metabolized to Agmatine and Ornithine. These are amino acids and often deficient in regular diets. Agmatine interacts with several molecular targets on nerve cells to provide neuro-protection and less nerve pain. Agmatine attenuates the pain-producing activity of glutamate, nicotine, NMDA and epinephrine. Agmatine regulates pain producing nitric oxide activity and serves as a building block for neuroprotective polyamines.
Caffeine is a central nervous system stimulant and is used to reduce physical fatigue and to prevent or treat drowsiness.  It produces increased wakefulness, increased focus, and better general body coordination.
Both caffeine and coffee are proven ergogenic aids in humans. Caffeine improves athletic performance in aerobic (especially endurance sports) and anaerobic conditions. Moderate doses of caffeine can improve sprint performance, cycling and running time trial performance, endurance (i.e., it delays the onset of muscle fatigue and central fatigue), and cycling power output.
Caffeine blocks receptors in the brain called, 'adenosines', which in turn induce relaxation and activate dopamine chemicals associated with both pain relief and energy. A study from the year 2009, summarized in Science Daily and conducted by the University of Illinois at Urbana Champaign indicates that small doses of caffeine prior to working out may prolong the duration of a person's exercise. It may also prohibit the pain a person might experience in their joints due to strenuous activity.
Vitamin D3 functions more like a hormone than a vitamin and could be considered misclassified. It has receptors in virtually every human tissue, which affect up to 1000 different gene functions.
Low D3 leads to poor bone mineralization which causes chronic dull muscoluskeletal aches and pains. Vitamin D3 decreases pro-inflammatory cytokines and increases anti-inflammatory ones.
Depending on time of year and region, up to 50-87% percent of adults are D3 deficient.
- Up to 70% of people in pain have D3 deficiency.
- Up to 96% of back pain patients given D3 supplementation had symptom relief.
- Neuropathic pain is relieved up to 50% with D3 supplementation.
- Migraine headaches and mood disorders are also proven to be reduced with D3 supplementation.